FB Kyle Juszczyk (knee), S Marques Sigle (high-ankle sprain), DE Nick Bosa (knee/calf, third straight missed game) and DT James Thompson Jr. (ankle, third straight missed game) are all out; CB Upton Stout (shoulder) is questionable.

Second-year DL Mykel Williams, who tore his ACL as a rookie, is eligible to make his 2026 debut against Seattle; he credited Nick Bosa, who had the same surgery, for helping his recovery.

The Bay Area-born lineman, waived Oct. 3 to make room for Sebastian Valdez, returns to the practice squad as the undefeated 49ers manage depth up front through a compressed schedule.

The NFL fined Greenlaw $11,941 for taunting the Broncos' bench and coach Sean Payton during San Francisco's Week 4 win, per a league source.

San Francisco is one of only three remaining unbeaten teams. Brock Purdy threw for 218 yards and 2 TDs, George Kittle's 56-yard touchdown catch sealed it, and coach Kyle Shanahan passed Bill Walsh for the most regular-season games coached in franchise history. FB Kyle Juszczyk (knee) is expected out a few weeks; an MRI ruled out the initially-feared ACL tear.

The NFL suspended York for six games and fined him $500,000 for a Personal Conduct Policy violation stemming from an August arrest in East Palestine, Ohio, to which he pleaded no contest to misdemeanor charges. Three games he had already voluntarily missed count toward the suspension; he is set to become eligible to resume his ownership activities around Oct. 20, with outlets citing Weeks 7-9 as the range for his first game back in attendance. 'I am deeply sorry,' York said in a statement. 'This was an inexcusable mistake and I take full responsibility.' He said he accepts the league's decision in full. It is the first league discipline of a 49ers owner since Eddie DeBartolo Jr.'s suspension in 1999.

San Francisco was missing Nick Bosa, Mykel Williams and James Thompson up front, with rookie LB Jaden Dugger also added to the injury list ahead of the team's game at Denver, which it won to stay 4-0.

San Francisco hosts Denver with coach Kyle Shanahan set to break the franchise record for games coached, in a 'Crucial Catch' game at Levi's Stadium.

San Francisco's top receiver is a game-time decision while a veteran edge rusher could make his 49ers debut off the practice squad.

The 2025 first-round pick returned to practice for the first time since last season's ACL tear, though he remains on PUP and can't play this week.

Two returning 2019 draft picks are contributing meaningfully to San Francisco's unbeaten start -- Samuel with 159 receiving yards and two touchdowns, Greenlaw with 22 tackles.

Purdy threw for 789 yards and 9 touchdowns with a league-leading 133.1 passer rating through three games, the first 49ers QB to win a monthly award since 2001.